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M94A3041.TXT
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1994-10-25
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Document 3041
DOCN M94A3041
TI Serum neopterin concentration in HIV infected IVDUs.
DT 9412
AU Rogowska-Szadkowska D; Borzuchowska A; Prokopowicz D; Grzeszczuk A;
Chodynicka B; Andrzejewicz A; Rogowski F; Dep. Infect. Dis., Medical
Sch., Bialystok, PL.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):167 (abstract no. PB0093). Unique
Identifier : AIDSLINE ICA10/94369534
AB OBJECTIVE: Analysis of changes in the serum concentration of neopterin
(NPT) in HIV infected IVDUs in relation to current using or not using
intravenous drugs. METHODS: NPT concentrations were measured using
radioimmunoassay (IMMUtest Neopterin-Henning Berlin) in the serum of 34
HIV positive asymptomatic IVDUs. Twenty of them abstained from drugs for
several months to more than a year (group A), the other 14 were active
drug users (group B). Testing was carried out repeatedly in 3-6 months
intervals. RESULTS: The results showed that mean NPT concentrations were
higher than normal in both groups (A-12, 32 +/- 4, 75, B-14, 58 +/- 5,
26 nmol/l). After 6-12 months of observation, NPT concentrations
decreased in the group A (10, 98 +/- 2, 77 nmol/l) and significantly
increased in the group B (23, 89 +/- 7, 7 nmol/l). CONCLUSIONS: In the
assessment of the prognostic value of NPT concentration in HIV infected
IVDUs the behavioral aspects must be considered.
DE Biopterin/*ANALOGS & DERIVATIVES/BLOOD Follow-Up Studies Human HIV
Infections/DIAGNOSIS/*IMMUNOLOGY/TRANSMISSION HIV
Seropositivity/DIAGNOSIS/IMMUNOLOGY/TRANSMISSION Substance Abuse,
Intravenous/COMPLICATIONS/*IMMUNOLOGY/ REHABILITATION MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).